Solution
This difference is expected. When comparing the block diagrams of the USB-6421 with the USB-6453 or USB-6451, we can see differences in the connections between the ADC and each channel.
For the USB-6451 or USB-6453, there is one ADC for each pair of differential channels, which can cause the error when using AI0 (Differential) and AI8 (RSE) simultaneously.

On the other hand, each AI channel is connected to the ADC through a multiplexer.
