Solution
On DAQ devices with a single ADC, a disconnected or open channel will impact the maximum achievable sample rate as long as it has been configured.
The DAQ device does not care whether a channel is reading correct values. As long as the channel has been configured (either in NI MAX or programmatically), it is considered an active channel. The maximum achievable sample rate is the aggregate sample rate divided by the total number of active channels. See
What Do "Maximum AI Sample Rate Single Channel and Aggregate" Values Mean? for further explanation.