You can use the PCIe-6321 instead of PCIe-6221. Just be aware that PCIe-6321 is an X-series module and PCIe-6221 is an M-series module. They may have minor differences, please check their specifications: NI 6221 Specifications and PCIe-6321 SpecificationsThe main difference is that the PCIe-6321 has four counters, and the PCIe-6221 has only two. Both modules have the same pinout (see below pictures):
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