Prior to version 2016 of the DSC module, a known issue prevented some applications built with Enhanced DSC Run-Time support from running, even if the code worked in the development environment. Therefore, for versions of the DSC module prior to 2016, it is not recommended to enable this setting.
The purpose of this setting is to allow you to manage project libraries and shared variables in applications built using the DSC Module. This setting does not affect whether or not the DSC Run-Time system is included with an installer. See What is the DSC Run-Time System and When Should I Use It?
for more information on the DSC Run-Time system.