Additional Information
The resolution difference is a result of how the ADC range is allocated in each measurement mode rather than a limitation of the hardware itself.
For newer NI USB data acquisition devices such as the USB-6001, USB-6002, and USB-6003, the analog input architecture differs from that of the USB-6008 and USB-6009. As a result, the ADC resolution specification remains the same regardless of whether the analog input channel is configured for differential or single-ended measurements.